Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Deoxyadenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.65 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PNP | P00491 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.57 |
| ▸ | GAPDH | P04406 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deoxyadenosine SCHEMBL27615805 | 1.00 | POLB (0.68) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL888220 | 1.00 | POLB (0.68) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL3410419 | 1.00 | POLB (0.68) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL8507956 | 0.96 | POLB (0.66) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL27801147 | 0.95 | POLB (0.73) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL23982174 | 0.94 | HIF1A (0.71) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL5982291 | 0.94 | HIF1A (0.71) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL5982298 | 0.94 | HIF1A (0.71) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL21637036 | 0.94 | HIF1A (0.71) | POLBHIF1AENPP1P2RY1SMN1; SMN2 | |
| Deoxyadenosine SCHEMBL193181 | 0.94 | HIF1A (0.71) | POLBHIF1AENPP1P2RY1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118109537-A | Application of halogenating enzyme in catalytic synthesis of 2' -halogenated nucleoside monophosphate | 香港中文大学（深圳） | 2024-05-31 | — | — | CN | claimed |
| US-20220401617-A1 | ADHESIVE COMPOSITIONS COMPRISING THERAPEUTICS | REVBIO INC (US) | 2022-12-22 | — | — | US | claimed |
| EP-4054548-A1 | ADHESIVE COMPOSITIONS COMPRISING THERAPEUTICS | RevBio, Inc. (US) | 2022-09-14 | — | — | EP | claimed |
| US-20250049488-A1 | DEVICES AND METHODS FOR BONE FIXATION | REVBIO INC (US) | 2025-02-13 | — | — | US | disclosed |
| US-20240368682-A1 | SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUCLEIC ACID MOLECULES FOR GENOMIC AND THERAPEUTIC APPLICATIONS | REDVAULT BIOSCIENCES LP (US) | 2024-11-07 | — | — | US | disclosed |
| EP-4447833-A2 | DEVICES AND METHODS FOR BONE FIXATION | RevBio, Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| US-20240180625-A1 | IMAGE GUIDED DELIVERY OF COMPOSITIONS AND RELATED METHODS | REVBIO INC (US) | 2024-06-06 | — | — | US | disclosed |
| CN-118109537-A | Application of halogenating enzyme in catalytic synthesis of 2' -halogenated nucleoside monophosphate | 香港中文大学（深圳） | 2024-05-31 | — | — | CN | disclosed |
| US-20230329755-A1 | BONE FLAP FIXATION DEVICE | REVBIO INC (US) | 2023-10-19 | — | — | US | disclosed |
| WO-2023114440-A2 | DEVICES AND METHODS FOR BONE FIXATION | RevBio, Inc. (US) | 2023-06-22 | — | — | WO | disclosed |
| EP-4164522-A1 | BONE FLAP FIXATION DEVICE | RevBio, Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-1729297-A | Preparation of deoxyribonucleotides by enzymatic reduction of ribonucleotides | SCINOPHARM SINGAPORE PTE LTD (CN) | 2006-02-01 | — | — | CN | disclosed |
| US-6677140-B2 | AMPLIFICATION OF PREFERENTIAL NUCLEOTIDE SEQUENCES; OBTAIN NUCLEIC ACID SAMPLE, INCUBATE WITH PRIMERS AND POLYMERASE, AMPLIFY, RECOVER NUCLEOTIDE SEQUENCES | PROMEGA CORPORATION | 2004-01-13 | — | — | US | disclosed |
| US-20020192677-A1 | Nucleic acid amplification with DNA-dependent RNA polymerase activity of RNA replicases | PROMEGA CORPORATION | 2002-12-19 | — | — | US | disclosed |
| US-6369207-B1 | FOR DETECTING NUCLEIC ACID ANALYTE IN A TEST SAMPLE | PROMEGA CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-6090589-A | USING CHIMERIC NUCLEIC ACID INCLUDING DNA NUCLEOTIDES AND AN RNA SEQUENCE WHICH CAN BE AUTOCATALYTICALLY REPLICATED | PROMEGA CORPORATION (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0519053-B1 | NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES | PROMEGA CORP (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0519053-A4 | NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES | — | 1993-03-31 | — | — | EP | disclosed |
| EP-0519053-A1 | NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES. | PROMEGA CORP (US) | 1992-12-23 | — | — | EP | disclosed |
| WO-1992012261-A1 | NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES | PROMEGA CORPORATION (US) | 1992-07-23 | — | — | WO | disclosed |