Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19774664 | 0.92 | SMN1; SMN2 (0.39) | KMT2AALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL19698817 | 0.89 | PKM (0.36) | KMT2AALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL22220123 | 0.84 | SMN1; SMN2 (0.39) | KMT2AALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL19684093 | 0.83 | SMN1; SMN2 (0.40) | KMT2AALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL22000808 | 0.82 | PKM (0.45) | KMT2AALDH1A1SMN1; SMN2PKMHPGD | |
| SCHEMBL22219876 | 0.81 | HTR1A (0.36) | KMT2AALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL19698840 | 0.81 | KMT2A (0.35) | KMT2AALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL22044805 | 0.81 | KMT2A (0.42) | KMT2AALDH1A1SMN1; SMN2PKMHPGD | |
| SCHEMBL25748806 | 0.81 | HDAC6 (0.41) | ALDH1A1SMN1; SMN2HPGDHTR1A | |
| SCHEMBL25748809 | 0.81 | HDAC6 (0.41) | ALDH1A1SMN1; SMN2HPGDHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464280-B1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2021-10-06 | — | — | EP | disclosed |
| EP-3033111-B1 | 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT | GENENTECH INC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-3082876-B1 | 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT | GENENTECH INC (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2017214024-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-14 | — | — | WO | disclosed |