Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618425 | 0.92 | FAAH (0.42) | FAAHFGFR4CSNK1DCSNK1ENEK2 | |
| SCHEMBL17618442 | 0.91 | FAAH (0.41) | FAAHFGFR4CSNK1DCSNK1ENEK2 | |
| SCHEMBL17618367 | 0.90 | FAAH (0.41) | FAAHFGFR4CSNK1DCSNK1E | |
| SCHEMBL17618456 | 0.90 | LRRK2 (0.41) | FAAHFGFR4USP30KCNH2 | |
| SCHEMBL19706218 | 0.90 | FAAH (0.41) | FAAHFGFR4CSNK1DCSNK1E | |
| SCHEMBL17618522 | 0.90 | FAAH (0.39) | FAAHFGFR4RPS6KA2SMPD3CYP2C9 | |
| SCHEMBL17618525 | 0.89 | FAAH (0.40) | FAAHFGFR4CSNK1DCSNK1ERPS6KA2 | |
| SCHEMBL17618531 | 0.89 | FAAH (0.40) | FAAHFGFR4CSNK1DCSNK1ENEK2 | |
| SCHEMBL17618558 | 0.89 | FAAH (0.40) | FAAHFGFR4CSNK1DCSNK1ENEK2 | |
| SCHEMBL17618447 | 0.89 | KIT (0.41) | FAAHFGFR4CSNK1DCSNK1ENEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | FAAH 977/4885FGFR4 1754/4885CSNK1D 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.