Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19700824 | 0.83 | TP53 (0.77) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19700820 | 0.77 | HTT (0.59) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19700819 | 0.76 | HTT (0.76) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19700803 | 0.76 | TP53 (1.00) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19700822 | 0.76 | TP53 (0.53) | TP53KDM4ELMNAMAPTHTT | |
| SCHEMBL8482469 | 0.75 | HTT (0.68) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL19700826 | 0.74 | TP53 (0.59) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19700821 | 0.74 | TP53 (0.77) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9921326 | 0.74 | HTT (0.44) | TP53ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL19700805 | 0.73 | KDM4E (0.70) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355700-A1 | PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS | NORTHERN ILLINOIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
| US-20170355700-A1 | PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS | NORTHERN ILLINOIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355700-A1 | PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS | DHPS, FDPS, IMPDH1 | TP53 4401/4885KDM4E 1149/4885TDP1 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.