Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970445 | 0.89 | PLG (0.40) | PLGPLATLMNANCF1CHRM2 | |
| SCHEMBL8262149 | 0.86 | PLG (0.38) | PLGPLATLMNANCF1CHRM2 | |
| SCHEMBL3296699 | 0.85 | CYP2C19 (0.41) | PLGPLATLMNANCF1CHRM2 | |
| SCHEMBL5114260 | 0.83 | HTR4 (0.34) | NCF1HTR4 | |
| SCHEMBL1971158 | 0.83 | GAA (0.40) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL1971581 | 0.80 | USP2 (0.35) | NCF1HTR4 | |
| SCHEMBL1971583 | 0.79 | CHRM2 (0.31) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2010650 | 0.78 | HTR4 (0.41) | NCF1HTR4ALDH1A1CXCR4 | |
| SCHEMBL1969361 | 0.78 | DPP4 (0.35) | ALDH1A1NPSR1L3MBTL1HSD17B10 | |
| SCHEMBL3714798 | 0.76 | HSD17B10 (0.48) | ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856110-B1 | OXYINDOLE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER (US) | 2011-06-22 | — | — | EP | disclosed |
| EP-1856110-A1 | OXYINDOLE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | Pfizer, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1758891-A2 | BENZIMIDAZOLONE CARBOXYLIC ACID DERIVATIVES | Pfizer Japan Inc. (JP) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006090279-A1 | OXYINDOLE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2006-08-31 | — | — | WO | disclosed |
| WO-2005123718-A2 | BENZIMIDAZOLONE CARBOXYLIC ACID DERIVATIVES | PFIZER JAPAN INC. (JP) | 2005-12-29 | — | — | WO | disclosed |