Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 8/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | MERTK | Q12866 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701787 | 0.74 | AXL (0.41) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL64684 | 0.72 | ACVRL1 (0.51) | ACVRL1AXLMERTKTYRO3ALDH1A1 | |
| SCHEMBL15826967 | 0.72 | AXL (0.54) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL19701784 | 0.72 | PIK3CD (0.48) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL12365553 | 0.72 | ALDH1A1 (0.43) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL66503 | 0.72 | ALDH1A1 (0.43) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL64680 | 0.71 | ALDH1A1 (0.42) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL19701785 | 0.69 | PIK3CD (0.46) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL19701786 | 0.69 | PIK3CD (0.47) | ACVRL1PIK3CDAXLMERTKTYRO3 | |
| SCHEMBL19701791 | 0.69 | ACVRL1 (0.44) | ACVRL1PIK3CDAXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | ACVRL1 2053/4885PIK3CD 14/4885AXL 1201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.