Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 9/20 | 0.35 |
| ▸ | MMP2 | P08253 | 7/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 3/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701947 | 0.85 | PIK3CD (0.38) | PIK3CDADAMTS5MMP2NOTUMCHRM1 | |
| SCHEMBL19710619 | 0.82 | PIK3CD (0.40) | PIK3CDADAMTS5MMP2NPY5R | |
| SCHEMBL19701948 | 0.82 | PIK3CD (0.40) | PIK3CDADAMTS5MMP2NOTUM | |
| SCHEMBL19690180 | 0.81 | PIK3CD (0.39) | PIK3CDADAMTS5MMP2MMP14NPY5R | |
| SCHEMBL19690181 | 0.81 | PIK3CD (0.39) | PIK3CDADAMTS5MMP2MMP14NPY5R | |
| SCHEMBL19701944 | 0.80 | NOTUM (0.52) | PIK3CDNOTUMCHRM1 | |
| SCHEMBL19701939 | 0.78 | PIK3CD (0.39) | PIK3CDADAMTS5MMP2NOTUMNPY5R | |
| SCHEMBL19703395 | 0.78 | PIK3CD (0.48) | PIK3CDADAMTS5MMP2NOTUMMMP14 | |
| SCHEMBL19710817 | 0.73 | NPSR1 (0.41) | PIK3CDADAMTS5MMP2NOTUM | |
| SCHEMBL19690165 | 0.68 | PIK3CD (0.38) | PIK3CDADAMTS5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | PIK3CD 14/4885ADAMTS5 4056/4885MMP2 2310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.