Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | CPS1 | P31327 | 10/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701947 | 0.83 | PIK3CD (0.38) | PIK3CDKDM4ENOTUMMMP2ADAMTS5 | |
| SCHEMBL19710622 | 0.83 | PIK3CD (0.42) | PIK3CDCPS1 | |
| SCHEMBL19690312 | 0.82 | PIK3CD (0.41) | PIK3CDCPS1 | |
| SCHEMBL19701945 | 0.82 | PIK3CD (0.39) | PIK3CDNOTUMMMP2ADAMTS5 | |
| SCHEMBL19690311 | 0.82 | PIK3CD (0.41) | PIK3CDCPS1 | |
| SCHEMBL19701944 | 0.80 | NOTUM (0.52) | PIK3CDKDM4ENOTUMHPGD | |
| SCHEMBL19701943 | 0.80 | PIK3CD (0.40) | PIK3CDCPS1KDM4ENOTUM | |
| SCHEMBL19703395 | 0.76 | PIK3CD (0.48) | PIK3CDNOTUMMMP2ADAMTS5 | |
| SCHEMBL19710817 | 0.71 | NPSR1 (0.41) | PIK3CDNOTUMMMP2ADAMTS5HPGD | |
| SCHEMBL23089808 | 0.71 | CPS1 (0.44) | CPS1ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | PIK3CD 14/4885CPS1 4049/4885KDM4E 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.