Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.67 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.52 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22055790 | 0.82 | PGR (0.72) | PGRNPEPPSERCC1FEN1ERCC4 | |
| SCHEMBL6360759 | 0.81 | PGR (1.00) | PGRNPEPPSERCC1FEN1ERCC4 | |
| SCHEMBL19702005 | 0.81 | BTK (0.52) | PGRGRM4MAPTRXFP1NOTUM | |
| SCHEMBL15496383 | 0.78 | KDM4E (0.53) | PPARGMAPTNOTUM | |
| SCHEMBL19342645 | 0.74 | KDM4E (0.48) | PPARGMAPTNOTUM | |
| SCHEMBL16352662 | 0.73 | ERCC1 (0.61) | PGRNPEPPSERCC1FEN1ERCC4 | |
| SCHEMBL12889781 | 0.73 | PGR (0.77) | PGRNPEPPSERCC1FEN1ERCC4 | |
| SCHEMBL5331459 | 0.70 | PGR (0.55) | PGRGRM4MAPTRXFP1 | |
| SCHEMBL12000729 | 0.70 | KDM4E (0.47) | PPARGNOTUM | |
| SCHEMBL31276926 | 0.70 | RORA (0.52) | PGRERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | PGR 1396/4885NPEPPS 4583/4885ERCC1 4103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.