Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19710506 | 0.82 | NPY5R (0.58) | NOTUMHTR2AHTR2CPIK3CDNPY5R | |
| SCHEMBL19658404 | 0.81 | NOTUM (0.58) | NOTUMHRH3PIK3CDNPY5R | |
| SCHEMBL19652215 | 0.80 | NOTUM (0.57) | NOTUMHRH3NPY5R | |
| SCHEMBL19702022 | 0.77 | NOTUM (0.54) | NOTUMHRH3PIK3CDNPY5R | |
| SCHEMBL19701981 | 0.76 | ALDH1A1 (0.50) | NOTUMHRH3 | |
| SCHEMBL16019525 | 0.76 | NOTUM (0.56) | NOTUMHRH3 | |
| SCHEMBL19702028 | 0.76 | NOTUM (0.62) | NOTUMHRH3PIK3CD | |
| SCHEMBL23844238 | 0.76 | NOTUM (0.58) | NOTUMHRH3 | |
| SCHEMBL25605922 | 0.76 | NOTUM (0.62) | NOTUMHRH3 | |
| SCHEMBL13929507 | 0.76 | NOTUM (0.58) | NOTUMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | NOTUM 3221/4885HRH3 61/4885HTR2A 2338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.