Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965700 | 0.90 | POLB (0.59) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL11934839 | 0.84 | KMT2A (0.53) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL13438704 | 0.84 | KMT2A (0.53) | POLBKDM4EKMT2AMEN1ATM | |
| Hydrochloric Acid SCHEMBL7272730 | 0.83 | SLC2A1 (0.60) | KDM4EKMT2AMEN1SLC2A1MAPT | |
| SCHEMBL1970788 | 0.81 | KMT2A (0.56) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL1967751 | 0.81 | CALM1 (0.53) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL1969966 | 0.79 | RECQL (0.48) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL2403138 | 0.79 | KMT2A (0.47) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL1968618 | 0.79 | PKM (0.47) | POLBKDM4EKMT2AMEN1ATM | |
| SCHEMBL1969543 | 0.79 | TAAR1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |