Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1968659 | 1.00 | MEN1 (0.65) | MEN1CYP1A2KMT2ACA1CA2 | |
| SCHEMBL1972152 | 0.87 | MEN1 (0.49) | MEN1CYP1A2KMT2ACA1CA2 | |
| SCHEMBL27338628 | 0.80 | MEN1 (0.71) | MEN1CYP1A2KMT2AALDH1A1LMNA | |
| SCHEMBL305912 | 0.80 | CYP1A2 (0.70) | MEN1CYP1A2KMT2AALDH1A1KIF11 | |
| SCHEMBL2089243 | 0.80 | CYP1A2 (0.70) | MEN1CYP1A2KMT2AALDH1A1KIF11 | |
| SCHEMBL2089245 | 0.80 | CYP1A2 (0.70) | MEN1CYP1A2KMT2AALDH1A1KIF11 | |
| SCHEMBL13073529 | 0.79 | MEN1 (1.00) | MEN1CYP1A2KMT2AALDH1A1TDP1 | |
| SCHEMBL7742622 | 0.79 | MEN1 (0.69) | MEN1CYP1A2KMT2AALDH1A1LMNA | |
| SCHEMBL21767930 | 0.79 | MEN1 (0.69) | MEN1CYP1A2KMT2ACA2ALDH1A1 | |
| SCHEMBL21767932 | 0.79 | MEN1 (0.69) | MEN1CYP1A2KMT2ACA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168667-B2 | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such | GALAPAGOS NV (BE) | 2012-05-01 | — | — | US | disclosed |
| EP-2026799-B1 | IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH | GALAPAGOS SAS (FR) | 2011-06-22 | — | — | EP | disclosed |