Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970323 | 0.87 | MEN1 (0.65) | MEN1CYP1A2KMT2AALDH1A1KIF11 | |
| SCHEMBL1968659 | 0.87 | MEN1 (0.65) | MEN1CYP1A2KMT2AALDH1A1KIF11 | |
| SCHEMBL1478852 | 0.81 | CYP1A2 (0.51) | MEN1CYP1A2KMT2AKIF11LMNA | |
| SCHEMBL8079775 | 0.80 | ALDH1A1 (0.49) | CYP1A2ALDH1A1KIF11CA1CA2 | |
| SCHEMBL4878584 | 0.76 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1KIF11CA1 | |
| SCHEMBL8775713 | 0.75 | KIF11 (0.47) | KMT2AALDH1A1KIF11MMP13 | |
| SCHEMBL8086879 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KIF11CA1CA2LMNA | |
| SCHEMBL3491598 | 0.74 | MAPT (0.50) | CYP1A2ALDH1A1KIF11CA1CA2 | |
| SCHEMBL2910709 | 0.74 | MAPT (0.50) | CYP1A2ALDH1A1KIF11CA1CA2 | |
| SCHEMBL3492765 | 0.74 | MAPT (0.50) | CYP1A2ALDH1A1KIF11CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168667-B2 | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such | GALAPAGOS NV (BE) | 2012-05-01 | — | — | US | disclosed |
| EP-2026799-B1 | IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH | GALAPAGOS SAS (FR) | 2011-06-22 | — | — | EP | disclosed |