Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15109556 | 0.75 | KCNMA1 (0.50) | KCNMA1ESR1KDM4ERAB9ANPC1 | |
| SCHEMBL20821949 | 0.75 | KCNMA1 (0.43) | KCNMA1KDM4ERAB9ATSHRSMN1; SMN2 | |
| SCHEMBL18703939 | 0.73 | GRM2 (0.52) | KCNMA1ESR1KDM4ERAB9ANPC1 | |
| SCHEMBL25873798 | 0.72 | KCNMA1 (0.50) | KCNMA1ESR1KDM4ERAB9ANPC1 | |
| SCHEMBL21337802 | 0.72 | KCNMA1 (0.47) | KCNMA1ESR1KDM4ERAB9ANPC1 | |
| SCHEMBL6528132 | 0.71 | KCNMA1 (0.53) | KCNMA1KDM4ERAB9ATSHRSMN1; SMN2 | |
| SCHEMBL20821940 | 0.71 | KCNMA1 (0.46) | KCNMA1ESR1KDM4ERAB9ATSHR | |
| SCHEMBL10429585 | 0.70 | KCNMA1 (0.55) | KCNMA1KDM4ERAB9ATSHRSMN1; SMN2 | |
| SCHEMBL12167112 | 0.70 | KCNMA1 (0.42) | KCNMA1ESR1KDM4ERAB9ANPC1 | |
| SCHEMBL12175671 | 0.70 | KMT2A (0.59) | KCNMA1ESR1KDM4ERAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214367-A1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS, INC. (US) | 2017-12-14 | — | — | WO | disclosed |