Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19705735 | 0.84 | GPBAR1 (0.42) | GPBAR1PPARDMRGPRX4MAPK14ULK1 | |
| SCHEMBL19738283 | 0.84 | GPBAR1 (0.42) | GPBAR1PPARDMRGPRX4MAPK14ULK1 | |
| SCHEMBL19705743 | 0.82 | KDM4E (0.43) | KDM4E | |
| SCHEMBL19698930 | 0.81 | GPBAR1 (0.40) | GPBAR1PPARDMRGPRX4MAPK14ULK1 | |
| SCHEMBL24565981 | 0.81 | GPBAR1 (0.39) | GPBAR1PPARDMRGPRX4MAPK14ULK1 | |
| SCHEMBL19725195 | 0.80 | GPBAR1 (0.40) | GPBAR1PPARDMRGPRX4MAPK14ULK1 | |
| SCHEMBL15601900 | 0.80 | GPBAR1 (0.42) | GPBAR1MRGPRX4TLR7MEN1KMT2A | |
| SCHEMBL19705749 | 0.79 | GPBAR1 (0.38) | GPBAR1PPARDMRGPRX4MAPK14ULK1 | |
| SCHEMBL19725183 | 0.79 | EGLN1 (0.41) | MAPTKDM4EATM | |
| SCHEMBL15601855 | 0.74 | MRGPRX4 (0.43) | GPBAR1PPARDMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739065-B2 | FXR (NR1H4) modulating compounds | GILEAD SCIENCES, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20220204460-A1 | FXR (NR1H4) MODULATING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2022-06-30 | — | — | US | disclosed |
| US-10981881-B2 | FXR (NR1H4) modulating compounds | GILEAD SCIENCES, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200369632-A1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2020-11-26 | — | — | US | disclosed |
| US-20200361920-A1 | ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2020-11-19 | — | — | US | disclosed |
| US-20190308962-A1 | FXR (NR1H4) Modulating Compounds | GILEAD SCIENCES, INC. (US) | 2019-10-10 | — | — | US | disclosed |
| US-20170355685-A1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190308962-A1 | FXR (NR1H4) Modulating Compounds | NR1H4, NR1H2, NR1H3 | GPBAR1 5/4885PPARD 42/4885MRGPRX4 278/4885 |
| US-10981881-B2 | FXR (NR1H4) modulating compounds | NR1H4, NR1H2, NR1H3 | GPBAR1 5/4885PPARD 42/4885MRGPRX4 296/4885 |
| US-11739065-B2 | FXR (NR1H4) modulating compounds | NR1H4, NR1H2, NR1H3 | GPBAR1 5/4885PPARD 42/4885MRGPRX4 296/4885 |
| US-20170355685-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | GPBAR1 5/4885PPARD 42/4885MRGPRX4 296/4885 |
| US-20200369632-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | GPBAR1 5/4885PPARD 42/4885MRGPRX4 296/4885 |
| US-20200361920-A1 | ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | SLC10A1, NR1H4, SLC10A2 | GPBAR1 6/4885PPARD 36/4885MRGPRX4 143/4885 |
| US-20220204460-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | GPBAR1 5/4885PPARD 42/4885MRGPRX4 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.