Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GCG | P01275 | 4/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 3/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19725183 | 0.86 | EGLN1 (0.41) | KDM4EALDH1A1HDAC6EGLN1CA1 | |
| SCHEMBL19705741 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1HPGDSIRT5ITGB3 | |
| SCHEMBL19705941 | 0.82 | GPBAR1 (0.43) | KDM4E | |
| SCHEMBL19698958 | 0.80 | GCG (0.43) | KDM4EALDH1A1HPGDSIRT5ITGB3 | |
| SCHEMBL15601898 | 0.79 | SIRT5 (0.47) | KDM4EALDH1A1HPGDSIRT5ITGB3 | |
| SCHEMBL3374192 | 0.78 | RAB9A (0.44) | KDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL14910728 | 0.74 | MAPK1 (0.44) | KDM4EALDH1A1POLBCA1CA2 | |
| SCHEMBL19705742 | 0.74 | GCGR (0.42) | KDM4EALDH1A1POLBGCGGCGR | |
| SCHEMBL15601803 | 0.73 | FABP4 (0.47) | ALDH1A1HPGDSIRT5POLBGCG | |
| SCHEMBL24530392 | 0.70 | CACNA1H (0.43) | SIRT5POLBGCGCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355685-A1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355685-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | KDM4E 3516/4885ALDH1A1 3805/4885HPGD 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.