Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 3/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141072 | 0.81 | MAPT (0.46) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL1964761 | 0.72 | ALDH1A1 (0.58) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL4788829 | 0.69 | ALDH1A1 (0.44) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL29360309 | 0.67 | SMN1; SMN2 (0.46) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL7380124 | 0.67 | SMN1; SMN2 (0.54) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL34473620 | 0.66 | LMNA (0.42) | MAPTGAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL3347382 | 0.65 | MAPT (1.00) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL940506 | 0.65 | MAPT (0.61) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL14423277 | 0.65 | PTGDR2 (0.41) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL3697057 | 0.64 | LMNA (0.51) | KDM4EALDH1A1LMNASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334676-A1 | SUBSTITUTED 3 -AMIN0- 1-0X0 OR THIOXO-I, 2,5,6,7, 8-HEXAHYDR0-2, 7-NAPHTHYRIDINE-4-CARB0NITRILES AS SELECTIVE ALPHA 2B ANTAGONISTS | Allergan, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |