Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 6/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26791964 | 0.76 | LOXL2 (0.35) | CBLBRXRAGRIN1GRIN2BLOXL2 | |
| SCHEMBL25499879 | 0.73 | HSP90AA1 (0.35) | CBLBCYP3A4TSHRHRH4CYP2D6 | |
| SCHEMBL179263 | 0.73 | LOXL2 (0.47) | LOXL2LOXKDM5B | |
| SCHEMBL17981924 | 0.72 | LOXL2 (0.45) | CBLBLOXL2CYP3A4LOX | |
| SCHEMBL20674836 | 0.72 | HSP90AA1 (0.34) | CBLBRXRAGRIN1GRIN2BLOXL2 | |
| SCHEMBL18855226 | 0.71 | LOXL2 (0.46) | CBLBRXRAGRIN1GRIN2BLOXL2 | |
| SCHEMBL18762885 | 0.70 | CASR (0.38) | CYP3A4TSHRCYP1A2ALOX15MAPK1 | |
| SCHEMBL18672470 | 0.69 | LOXL2 (0.44) | CBLBRXRAGRIN1GRIN2BLOXL2 | |
| SCHEMBL25987180 | 0.67 | CYP3A4 (0.35) | CBLBCYP3A4TSHRCYP2D6CRHBP | |
| SCHEMBL26774132 | 0.66 | LOXL2 (0.41) | CBLBRXRAGRIN1GRIN2BLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MDM2 1466/4885CBLB 4471/4885RXRA 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.