Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256851 | 0.95 | PDPK1 (0.39) | IDO1PDPK1SIGMAR1SRD5A1 | |
| SCHEMBL121704 | 0.92 | PDPK1 (0.43) | IDO1PDPK1SIGMAR1SRD5A1 | |
| SCHEMBL4904876 | 0.91 | SIGMAR1 (0.43) | IDO1SIGMAR1 | |
| SCHEMBL316316 | 0.81 | SRD5A1 (0.41) | IDO1PDPK1SIGMAR1SRD5A1 | |
| SCHEMBL6784204 | 0.77 | IDO1 (0.53) | IDO1PDPK1SIGMAR1SRD5A1 | |
| SCHEMBL145977 | 0.77 | IDO1 (0.57) | IDO1SIGMAR1 | |
| SCHEMBL29357487 | 0.77 | IDO1 (0.57) | IDO1SIGMAR1 | |
| SCHEMBL2257437 | 0.76 | PDPK1 (0.43) | IDO1PDPK1SIGMAR1SRD5A1 | |
| SCHEMBL815114 | 0.74 | MEN1 (0.38) | — | |
| SCHEMBL9528772 | 0.74 | IGF1R (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613599-B8 | A PROCESS FOR THE PREPARATION OF 5-(HALOACETYL)-8-(SUBSTITUTED OXY)-(1H)-QUINOLIN-2-ONES | NOVARTIS AG (CH) | 2011-06-22 | — | — | EP | disclosed |