Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.57 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.56 |
| ▸ | DPP4 | P27487 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 5/20 | 0.46 |
| ▸ | KLK7 | P49862 | 2/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19708141 | 1.00 | DPP8 (0.57) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL21009950 | 0.99 | DPP8 (0.56) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL20873003 | 0.94 | DPP8 (0.58) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL26120901 | 0.84 | TGM2 (0.58) | ITGB3ITGA2BTGM2KLK7KLK5 | |
| SCHEMBL26120906 | 0.84 | TGM2 (0.58) | ITGB3ITGA2BTGM2KLK7KLK5 | |
| SCHEMBL25597448 | 0.83 | MAPT (0.43) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL28302014 | 0.83 | DPP7 (0.61) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL28302016 | 0.83 | DPP7 (0.61) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL21009797 | 0.82 | MEN1 (0.40) | DPP8DPP7DPP9DPP4MAPT | |
| SCHEMBL19708418 | 0.82 | MEN1 (0.40) | DPP8DPP7DPP9DPP4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466962-A1 | PHENYL PROPANAMIDE DERIVATIVE, AND MANUFACTURING METHOD AND PHARMACEUTICAL APPLICATION THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017211272-A1 | PHENYL PROPANAMIDE DERIVATIVE, AND MANUFACTURING METHOD AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2017-12-14 | — | — | WO | disclosed |