Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 17/20 | 0.63 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.60 |
| ▸ | MMP13 | P45452 | 5/20 | 0.60 |
| ▸ | MMP2 | P08253 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19691576 | 0.87 | ADAMTS5 (0.82) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 | |
| SCHEMBL19996701 | 0.81 | ADAMTS5 (0.75) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 | |
| SCHEMBL19691675 | 0.77 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 | |
| SCHEMBL17871342 | 0.75 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 | |
| SCHEMBL17871295 | 0.75 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 | |
| SCHEMBL20708596 | 0.74 | ADAMTS5 (0.80) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL22201047 | 0.74 | ADAMTS5 (0.45) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 | |
| SCHEMBL23901338 | 0.73 | ADAMTS5 (0.71) | ADAMTS5ADAM17MMP13MMP2 | |
| SCHEMBL22201043 | 0.73 | ADAMTS5 (0.57) | ADAMTS5ADAM17MMP13MMP2 | |
| SCHEMBL17871553 | 0.73 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017211666-A1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2017-12-14 | — | — | WO | disclosed |