Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.75 |
| ▸ | MMP2 | P08253 | 11/20 | 0.75 |
| ▸ | MMP13 | P45452 | 9/20 | 0.75 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871178 | 0.85 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAM17ADAMTS4 | |
| SCHEMBL23901338 | 0.81 | ADAMTS5 (0.71) | ADAMTS5MMP2MMP13ADAM17 | |
| SCHEMBL19709309 | 0.81 | ADAMTS5 (0.63) | ADAMTS5MMP2MMP13ADAM17ADAMTS4 | |
| SCHEMBL23901276 | 0.80 | ADAMTS5 (0.75) | ADAMTS5MMP2MMP13ADAM17 | |
| SCHEMBL22201043 | 0.76 | ADAMTS5 (0.57) | ADAMTS5MMP2MMP13ADAM17 | |
| SCHEMBL23901408 | 0.76 | ADAMTS5 (0.71) | ADAMTS5MMP2MMP13ADAM17 | |
| SCHEMBL17871415 | 0.75 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAM17 | |
| SCHEMBL23901340 | 0.73 | ADAMTS5 (0.73) | ADAMTS5MMP2MMP13ADAM17ADAMTS4 | |
| SCHEMBL22201051 | 0.73 | ADAMTS5 (0.73) | ADAMTS5MMP2ADAM17ADAMTS4 | |
| SCHEMBL17871386 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAM17ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926281-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2018-03-27 | — | — | US | disclosed |