Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1971117 | 0.93 | HSD11B1 (0.45) | HSD11B1IDH1MAPT | |
| SCHEMBL1975069 | 0.84 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL1969592 | 0.84 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL1973300 | 0.82 | HSD11B1 (0.48) | HSD11B1TSHRIDH1KMT2ASMN1; SMN2 | |
| SCHEMBL4449144 | 0.78 | HSD11B1 (0.43) | HSD11B1TSHRIDH1MEN1KMT2A | |
| SCHEMBL1968877 | 0.76 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL1979989 | 0.76 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL1973571 | 0.75 | HSD11B1 (0.43) | HSD11B1ALDH1A1 | |
| SCHEMBL2006694 | 0.74 | HSD11B1 (0.60) | HSD11B1HPGDTSHRIDH1MAPT | |
| SCHEMBL1967906 | 0.74 | HSD11B1 (0.42) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-B8 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-06-22 | — | — | EP | claimed |
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | claimed |