Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1973300 | 0.97 | HSD11B1 (0.48) | HSD11B1EPHX1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1973692 | 0.83 | NPC1 (0.42) | HSD11B1EPHX1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1972181 | 0.83 | HSD11B1 (0.64) | HSD11B1IDH1 | |
| SCHEMBL1975071 | 0.81 | IDH1 (0.49) | HSD11B1EPHX1EPHX2CNR2CNR1 | |
| SCHEMBL1970498 | 0.81 | HSD11B1 (0.41) | HSD11B1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL1971013 | 0.79 | SLC6A12 (0.54) | HSD11B1EPHX1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1972364 | 0.79 | CNR2 (0.41) | HSD11B1RAB9AL3MBTL1CNR2CNR1 | |
| SCHEMBL4455215 | 0.78 | HSD11B1 (0.39) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL1969400 | 0.78 | HSD11B1 (0.51) | HSD11B1CNR2CNR1IDH1 | |
| SCHEMBL1970986 | 0.78 | HSD11B1 (0.51) | HSD11B1NPC1RAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | claimed |