Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054517 | 0.88 | IAPP (0.49) | IAPPMEP1BKMT2AAKR1B1 | |
| SCHEMBL19692985 | 0.87 | ERCC1 (0.44) | HDAC3HDAC1HDAC2NCOR2ERCC1 | |
| SCHEMBL19304783 | 0.85 | AKR1B1 (0.47) | IAPPKMT2AALOX5AKR1B1PIM1 | |
| SCHEMBL25438214 | 0.79 | HDAC3 (0.40) | KMT2AHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL31632682 | 0.79 | HDAC3 (0.40) | KMT2AHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL24277139 | 0.79 | MEP1B (0.41) | MEP1BKMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL24277635 | 0.75 | TRPV1 (0.43) | MEP1BKMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL29521027 | 0.75 | TRPV1 (0.43) | MEP1BKMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL27682022 | 0.74 | HDAC2 (0.46) | MEP1BHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL25410737 | 0.74 | TRPV1 (0.40) | KMT2AHDAC3HDAC1HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040647-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | CEDARS-SINAI MEDICAL CENTER (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2017213897-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | CEDARS-SINAI MEDICAL CENTER (US) | 2017-12-14 | — | — | WO | disclosed |