Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.49 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP16 | P51512 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19710337 | 0.88 | IAPP (0.42) | IAPPMEP1BKMT2AAKR1B1 | |
| SCHEMBL28400880 | 0.84 | MEN1 (0.45) | KMT2AMEN1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL28717700 | 0.79 | IAPP (0.56) | IAPPAKR1B1ALOX15MMP2MMP9 | |
| SCHEMBL19304783 | 0.79 | AKR1B1 (0.47) | IAPPKMT2AAKR1B1ALDH1A1LMNA | |
| SCHEMBL8791 | 0.78 | AKR1B1 (0.72) | IAPPKMT2AMEN1AKR1B1ALOX15 | |
| SCHEMBL29829095 | 0.78 | AKR1B1 (0.72) | IAPPKMT2AMEN1AKR1B1ALOX15 | |
| SCHEMBL31013617 | 0.76 | IAPP (0.67) | IAPPAKR1B1ALOX15MMP2MMP9 | |
| SCHEMBL1426061 | 0.76 | IAPP (0.67) | IAPPAKR1B1ALOX15MMP2MMP9 | |
| SCHEMBL11029713 | 0.76 | GAA (0.53) | IAPPAKR1B1ALOX15MMP2MMP9 | |
| SCHEMBL25285645 | 0.76 | IAPP (0.51) | IAPPAKR1B1ALOX15TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448730-A | ANTITUMOR AGENTS | RIET BARTHOLOMEUS VAN T | 1984-05-15 | — | — | US | disclosed |