Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19712426 | 0.91 | SRC (0.46) | PIK3CAPIK3CGPIK3CBPIK3CDAKT1 | |
| SCHEMBL2129041 | 0.85 | ALDH1A1 (0.48) | KMT2APIK3CAPIK3CGMAPTKDM4E | |
| SCHEMBL2129047 | 0.85 | ALDH1A1 (0.48) | KMT2APIK3CAPIK3CGMAPTKDM4E | |
| SCHEMBL19712414 | 0.84 | KMT2A (0.44) | KMT2APIK3CAPIK3CGMAPTKDM4E | |
| SCHEMBL19712449 | 0.83 | KMT2A (0.44) | KMT2APIK3CAPIK3CGMAPTKDM4E | |
| SCHEMBL19712378 | 0.83 | KMT2A (0.44) | KMT2APIK3CAPIK3CGMAPTKDM4E | |
| SCHEMBL19712387 | 0.76 | PIK3CA (0.40) | PIK3CAPIK3CGMAPTKDM4EALDH1A1 | |
| SCHEMBL19712429 | 0.75 | S1PR3 (0.43) | KMT2APIK3CAPIK3CGMAPTKDM4E | |
| SCHEMBL2129958 | 0.75 | SRC (0.45) | PIK3CAPIK3CGALDH1A1PIK3CBPIK3CD | |
| SCHEMBL2129961 | 0.75 | SRC (0.45) | PIK3CAPIK3CGALDH1A1PIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630123-B1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | claimed |