Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19712378 | 0.91 | KMT2A (0.44) | NAPEPLDKMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL19712446 | 0.90 | PPARG (0.42) | THRBNAPEPLDMEN1KMT2ANPC1 | |
| SCHEMBL19712445 | 0.87 | PIK3CA (0.42) | THRBENPP2MEN1KMT2APIK3CD | |
| SCHEMBL19712441 | 0.86 | PIK3CA (0.40) | NAPEPLDNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL19712450 | 0.86 | THRB (0.47) | THRBENPP2NAPEPLDMEN1KMT2A | |
| SCHEMBL19712423 | 0.85 | SRC (0.46) | NAPEPLDPIK3CBPIK3CDPIK3CA | |
| SCHEMBL19712380 | 0.85 | THRB (0.46) | THRBENPP2NAPEPLDMEN1KMT2A | |
| SCHEMBL2128777 | 0.84 | MEN1 (0.51) | THRBENPP2NAPEPLDMEN1KMT2A | |
| SCHEMBL19712432 | 0.84 | THRB (0.45) | THRBENPP2NAPEPLDKDM4EALDH1A1 | |
| SCHEMBL19712372 | 0.84 | THRB (0.44) | THRBENPP2NAPEPLDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630123-B1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | claimed |