Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 5/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19712400 | 0.92 | PIK3CD (0.42) | PIK3CAPIK3CDMTORKMT2AATR | |
| SCHEMBL19712421 | 0.88 | MTOR (0.40) | PIK3CAPIK3CDMTORENPP2MEN1 | |
| SCHEMBL19712422 | 0.87 | THRB (0.47) | PIK3CAPIK3CDENPP2MEN1KMT2A | |
| SCHEMBL19712444 | 0.86 | MDM2 (0.42) | PIK3CAPIK3CDMTORENPP2MEN1 | |
| SCHEMBL2129094 | 0.86 | MEN1 (0.47) | PIK3CAPIK3CDMTORENPP2MEN1 | |
| SCHEMBL19712390 | 0.81 | ATR (0.41) | PIK3CAPIK3CDMTORATRRAF1 | |
| SCHEMBL19712399 | 0.80 | MTOR (0.40) | PIK3CAPIK3CDMTORKMT2AATR | |
| SCHEMBL19712378 | 0.79 | KMT2A (0.44) | PIK3CAPIK3CDMTORKMT2A | |
| SCHEMBL19712417 | 0.78 | POLB (0.41) | PIK3CAPIK3CDMTORKMT2AATR | |
| SCHEMBL19712427 | 0.77 | MTOR (0.38) | PIK3CAPIK3CDMTORKMT2AATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630123-B1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | claimed |