Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19712388 | 0.93 | SRC (0.47) | SRCPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19712405 | 0.86 | SRC (0.47) | SRCPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19712372 | 0.86 | THRB (0.44) | PIK3CBPIK3CDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL2130463 | 0.86 | SRC (0.45) | SRCPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19712423 | 0.85 | SRC (0.46) | SRCPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19712418 | 0.84 | SRC (0.47) | SRCPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19712387 | 0.84 | PIK3CA (0.40) | PIK3CAPIK3CBPIK3CDPIK3CGGBA1 | |
| SCHEMBL19712447 | 0.83 | SRC (0.46) | SRCPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19712414 | 0.83 | KMT2A (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL19712426 | 0.83 | SRC (0.46) | SRCPIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630123-B1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | claimed |