Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.71 |
| ▸ | CREB1 | P16220 | 6/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.71 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.71 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.71 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.71 |
| ▸ | PTPRS | Q13332 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | GABRP | O00591 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Baicalein SCHEMBL29200768 | 0.86 | ABCB1 (0.89) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL28365951 | 0.83 | ABCB1 (0.94) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL5695785 | 0.83 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL29385549 | 0.83 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL139617 | 0.83 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| SCHEMBL6245328 | 0.82 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL28372093 | 0.82 | ABCB1 (0.97) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL28630648 | 0.82 | ABCB1 (0.97) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL28826034 | 0.82 | ABCB1 (0.97) | ABCB1CREB1CYP3A4MAPTMEN1 | |
| Baicalein SCHEMBL28206740 | 0.82 | ABCB1 (0.97) | ABCB1CREB1CYP3A4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10471054-B2 | CDK1 inhibitors of acetyl chrysin mannich base derivatives, synthesis and use thereof | Zhang, Fan (CN) | 2019-11-12 | — | — | US | claimed |
| US-20190216792-A1 | CDK1 INHIBITORS OF ACETYL CHRYSIN MANNICH BASE DERIVATIVES, SYNTHESIS AND USE THEREOF | ZHANG, FAN (CN) | 2019-07-18 | — | — | US | claimed |
| US-10471054-B2 | CDK1 inhibitors of acetyl chrysin mannich base derivatives, synthesis and use thereof | Zhang, Fan (CN) | 2019-11-12 | — | — | US | disclosed |
| US-10471054-B2 | CDK1 inhibitors of acetyl chrysin mannich base derivatives, synthesis and use thereof | Zhang, Fan (CN) | 2019-11-12 | — | — | US | disclosed |
| US-20190216792-A1 | CDK1 INHIBITORS OF ACETYL CHRYSIN MANNICH BASE DERIVATIVES, SYNTHESIS AND USE THEREOF | ZHANG, FAN (CN) | 2019-07-18 | — | — | US | disclosed |
| US-20190216792-A1 | CDK1 INHIBITORS OF ACETYL CHRYSIN MANNICH BASE DERIVATIVES, SYNTHESIS AND USE THEREOF | ZHANG, FAN (CN) | 2019-07-18 | — | — | US | disclosed |
| WO-2017215538-A1 | MANNICH BASE DERIVATIVE OF ACETYLCHRYSIN AND USE THEREOF | 张帆 | 2017-12-21 | — | — | WO | disclosed |
| CN-1300134-C | Baicalin preparing process | NANJING LAI ER BIOCHEMICAL CO (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1673222-A | Baicalin preparing process | NANJING LAI ER BIOCHEMICAL CO (CN) | 2005-09-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190216792-A1 | CDK1 INHIBITORS OF ACETYL CHRYSIN MANNICH BASE DERIVATIVES, SYNTHESIS AND USE THEREOF | CDK1, CDK12, CDK18 | ABCB1 3544/4885CREB1 2344/4885CYP3A4 1525/4885 |
| US-10471054-B2 | CDK1 inhibitors of acetyl chrysin mannich base derivatives, synthesis and use thereof | CDK1, CDK12, CDK18 | ABCB1 3544/4885CREB1 2344/4885CYP3A4 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.