Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 9/20 | 0.40 |
| ▸ | CTSK | P43235 | 8/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19696953 | 1.00 | SCN9A (0.41) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL19696793 | 0.88 | CACNA1B (0.44) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL18788876 | 0.86 | SCN9A (0.43) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL18788875 | 0.86 | SCN9A (0.43) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL15856095 | 0.85 | ITGB3 (0.43) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL19696788 | 0.83 | CNR2 (0.41) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL15962607 | 0.83 | ITGB3 (0.43) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL15856091 | 0.83 | ITGB3 (0.43) | SCN9ACTSSCTSKITGB3ITGA2B | |
| SCHEMBL15856090 | 0.83 | CTSS (0.46) | SCN9ACTSSCTSKTACR1ACE | |
| SCHEMBL15856088 | 0.83 | CTSS (0.46) | SCN9ACTSSCTSKTACR1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2940007-B1 | TYROSINE DERIVATIVE AND MANUFACTURING METHOD FOR TYROSINE DERIVATIVE | NARD INSTITUTE LTD (JP) | 2017-12-20 | — | — | EP | disclosed |