Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19190253 | 0.89 | ALDH1A1 (0.38) | ALDH1A1MEN1MAPTKMT2ACHEK2 | |
| SCHEMBL16895750 | 0.81 | MEN1 (0.39) | ALDH1A1MEN1MAPTKMT2ACHEK2 | |
| SCHEMBL16896132 | 0.78 | EGFR (0.57) | — | |
| SCHEMBL16901742 | 0.77 | MEN1 (0.40) | ALDH1A1MEN1MAPTKMT2ACHEK2 | |
| SCHEMBL19720567 | 0.77 | BTK (0.36) | ALDH1A1MEN1KMT2ACHEK2BTK | |
| SCHEMBL19720598 | 0.76 | MEN1 (0.37) | ALDH1A1MEN1MAPTKMT2APIK3CD | |
| SCHEMBL19720620 | 0.75 | MEN1 (0.35) | ALDH1A1MEN1MAPTKMT2ACHEK2 | |
| SCHEMBL16903327 | 0.72 | USP30 (0.42) | ALDH1A1MEN1MAPTKMT2ANSD2 | |
| SCHEMBL16895972 | 0.70 | RPS6KB1 (0.49) | ALDH1A1CHEK2L3MBTL1BTKSCN9A | |
| SCHEMBL16895971 | 0.70 | RPS6KB1 (0.49) | ALDH1A1CHEK2L3MBTL1BTKSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257848-A1 | COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY | Novartis AG (CH) | 2017-12-20 | — | — | EP | disclosed |