Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19720602 | 0.84 | HPGD (0.39) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL19720600 | 0.76 | ALDH1A1 (0.37) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL19720566 | 0.75 | USP30 (0.35) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL16903327 | 0.74 | USP30 (0.42) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL19720620 | 0.72 | MEN1 (0.35) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL19720435 | 0.71 | CYP2C9 (0.41) | GPR119USP30 | |
| SCHEMBL19190253 | 0.70 | ALDH1A1 (0.38) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL19190254 | 0.69 | HPGD (0.41) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL15506212 | 0.66 | ESR2 (0.50) | MEN1MAPTKMT2AGPR119USP30 | |
| SCHEMBL19720586 | 0.66 | USP30 (0.43) | MEN1ALDH1A1MAPTKMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257848-A1 | COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY | Novartis AG (CH) | 2017-12-20 | — | — | EP | disclosed |