Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603004 | 0.81 | PDK2 (0.42) | KDM4EALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL13603003 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL13315460 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL13385019 | 0.76 | PDGFRB (0.43) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL14810489 | 0.75 | HTR4 (0.58) | KDM4EALDH1A1LMNAPOLBHTR4 | |
| SCHEMBL4471489 | 0.75 | KDM4E (0.44) | KDM4EALDH1A1LMNAHSD17B10POLB | |
| SCHEMBL6848305 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL13603005 | 0.73 | FABP3 (0.39) | KDM4EALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL15502345 | 0.72 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL7398883 | 0.71 | KDM4E (0.58) | KDM4EALDH1A1LMNAHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709989-B1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2017-12-20 | — | — | EP | disclosed |