Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19723759 | 0.92 | LMNA (0.64) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL19723547 | 0.90 | LMNA (0.61) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL19723718 | 0.85 | LMNA (0.57) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL19723811 | 0.84 | KDM4E (0.71) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL19723756 | 0.84 | LMNA (0.59) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL1649578 | 0.82 | ROCK2 (0.61) | ROCK2PRKACAROCK1 | |
| SCHEMBL19723792 | 0.82 | LMNA (0.59) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL19723667 | 0.81 | KDM4E (0.76) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL17676521 | 0.80 | ROCK2 (0.50) | LMNAHTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL12779966 | 0.80 | ROCK1 (0.60) | LMNAHTTSMN1; SMN2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257854-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | University of Notre Dame du Lac (US) | 2017-12-20 | — | — | EP | disclosed |