SCHEMBL19723959

SCHEMBL19723959

C=C(/N=C(\N=C(/C)c1ccc(C)cc1)c1ccc(-c2ccc3ccc(-c4ccc(C(=N/C(=C)c5ccc(C)cc5)/N=C(\C)c5ccc(C)cc5)cc4)cc3c2)cc1)c1ccc(C)cc1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.36
RARA P10276 3/20 0.34
RARB P10826 3/20 0.34
RARG P13631 3/20 0.34
HSD11B1 P28845 1/20 0.34
UTS2R Q9UKP6 2/20 0.33
ESR1 P03372 2/20 0.33
ESR2 Q92731 2/20 0.33
CYP17A1 P05093 1/20 0.32
CYP19A1 P11511 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
CTRC Q99895 1/20 0.32
MCL1 Q07820 1/20 0.31
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22448436 0.78 MAPT (0.39) CYP1A2
SCHEMBL20611811 0.77 PDK2 (0.34) RARARARBRARGESR1ESR2
SCHEMBL20611815 0.76 ESR1 (0.42) ESR1ESR2
SCHEMBL16309370 0.76 CYP2A6 (0.39) CYP2A6CYP1A2
SCHEMBL18901271 0.73 ALDH1A1 (0.39) ESR1ESR2CYP1A2
SCHEMBL19368839 0.72 MEN1 (0.32) CYP1A2
SCHEMBL26289927 0.72 ESR1 (0.40) HSD11B1ESR1ESR2
SCHEMBL19723728 0.72
SCHEMBL19421378 0.71 SMN1; SMN2 (0.43) CYP1A2
SCHEMBL18868807 0.71 LMNA (0.40) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2749625-B1 ORGANIC LIGHT EMITTING DIODE LG CHEMICAL LTD (KR) 2017-12-20 EP disclosed