Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15652289 | 0.78 | HPGD (0.61) | HDAC1HDAC6KDM4EHDAC3NPC1 | |
| SCHEMBL26838909 | 0.77 | POLB (0.63) | HDAC1HDAC6KDM4ENPC1RAB9A | |
| SCHEMBL10090803 | 0.76 | MAPK14 (0.70) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5044729 | 0.75 | HDAC1 (0.41) | HDAC1HDAC6KDM4ENPC1RAB9A | |
| SCHEMBL29950977 | 0.74 | ALDH1A1 (0.52) | NPC1RAB9APOLBLMNASMN1; SMN2 | |
| SCHEMBL7215753 | 0.74 | ALDH1A1 (0.52) | NPC1RAB9APOLBLMNASMN1; SMN2 | |
| SCHEMBL3647392 | 0.72 | RAB9A (0.58) | HDAC1KDM4EHDAC3HDAC2NPC1 | |
| SCHEMBL15886864 | 0.71 | TUBB1 (0.51) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL4762998 | 0.70 | NPC1 (0.66) | HDAC1HDAC6KDM4EHDAC3HDAC2 | |
| SCHEMBL16371435 | 0.70 | KIT (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077387-B1 | BENZAMIDE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-20 | — | — | EP | disclosed |