Epigallocatechin

Epigallocatechin

SCHEMBL1972938

Oc1cc(O)c2c(c1)O[C@@H](c1cc(O)c(O)c(O)c1)[C@@H](O)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 6/20 1.00
▸ KDM4E B2RXH2 6/20 1.00
▸ PTGS1 P23219 5/20 1.00
▸ SNCA P37840 4/20 1.00
▸ MAPT P10636 4/20 1.00
▸ APEX1 P27695 4/20 1.00
▸ RECQL P46063 4/20 1.00
▸ HSD17B10 Q99714 4/20 1.00
▸ ALDH1A1 P00352 3/20 1.00
▸ HPGD P15428 3/20 1.00
▸ ALOX15 P16050 3/20 1.00
▸ TDP1 Q9NUW8 3/20 1.00
▸ RAD52 P43351 2/20 1.00
▸ CNR1 P21554 1/20 1.00
▸ MEN1 O00255 4/20 0.74
▸ KMT2A Q03164 4/20 0.74
▸ GAA P10253 3/20 0.74
▸ CYP3A4 P08684 3/20 0.74
▸ PKM P14618 2/20 0.74
▸ PTGS2 P35354 2/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Epigallocatechin SCHEMBL29870730 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
(-)-Gallocatechin SCHEMBL30159803 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Epigallocatechin SCHEMBL20203645 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Epigallocatechin SCHEMBL12840936 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Epigallocatechin SCHEMBL1972940 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Epigallocatechin SCHEMBL12285364 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Epigallocatechin SCHEMBL19553 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
(-)-Gallocatechin SCHEMBL1742127 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Gallocatechin SCHEMBL3872234 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT
Epigallocatechin SCHEMBL29929503 1.00 BACE1 (1.00) BACE1KDM4EPTGS1SNCAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117942405-A Compositions and methods for protecting airborne pathogens and irritants 应用生物实验室公司 2024-04-30 — — CN claimed
CN-114391574-B Color-protecting antioxidant for stabilized tea Huang Surou product and preparation method thereof 中华全国供销合作总社杭州茶叶研究所 2024-06-14 — — CN disclosed
CN-117942405-A Compositions and methods for protecting airborne pathogens and irritants 应用生物实验室公司 2024-04-30 — — CN disclosed
CN-115348821-A Novel nutrient for enhancing load-induced muscle hypertrophy 加利福尼亚大学董事会 2022-11-15 — — CN disclosed
CN-115068465-A Application of gallocatechin-7-gallate in anti-coronavirus drugs 中国医学科学院药物研究所 2022-09-20 — — CN disclosed
CN-114391574-A Stable theaflavin meat product color-protecting antioxidant and preparation method thereof 中华全国供销合作总社杭州茶叶研究所 2022-04-26 — — CN disclosed
US-20180243260-A1 METHODS OF TREATING COGNITIVE AND BEHAVIORAL IMPAIRMENT IN DOWN SYNDROME AND ALZHEIMERS DISEASE PATIENTS AVANTI BIOSCIENCES, INC. 2018-08-30 — — US disclosed
US-20180000774-A1 METHODS OF TREATING COGNITIVE AND BEHAVIORAL IMPAIRMENT IN DOWN SYNDROME AND ALZHEIMERS DISEASE PATIENTS AVANTI BIOSCIENCES, INC (US) 2018-01-04 — — US disclosed
US-20170355932-A1 CLEANING COMPOSITIONS INCLUDING NUCLEASE ENZYME AND TANNINS THE PROCTER & GAMBLE COMPANY 2017-12-14 — — US disclosed
US-20170355932-A1 CLEANING COMPOSITIONS INCLUDING NUCLEASE ENZYME AND TANNINS THE PROCTER & GAMBLE COMPANY 2017-12-14 — — US disclosed
EP-2637649-A2 COMPOUNDS AND METHODS FOR TREATING PAIN Akron Molecules GmbH (AT) 2013-09-18 — — EP disclosed
WO-2012062925-A2 COMPOUNDS AND METHODS FOR TREATING PAIN AKRON MOLECULES GMBH (AT) 2012-05-18 — — WO disclosed
US-20110144125-A1 Anti-Arrhythmia Agents, Methods of Their Use, Methods of Their Identification and Kits Therefore THE UAB RESEARCH FOUNDATION (US) 2011-06-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180243260-A1 METHODS OF TREATING COGNITIVE AND BEHAVIORAL IMPAIRMENT IN DOWN SYNDROME AND ALZHEIMERS DISEASE PATIENTS CHAT, CAMK2A, CAMK1G BACE1 143/4885KDM4E 2235/4885PTGS1 2196/4885
US-20180000774-A1 METHODS OF TREATING COGNITIVE AND BEHAVIORAL IMPAIRMENT IN DOWN SYNDROME AND ALZHEIMERS DISEASE PATIENTS CHAT, CAMK2A, CAMK1G BACE1 132/4885KDM4E 1759/4885PTGS1 2239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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