Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 8/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15266506 | 0.88 | CNR1 (0.41) | CNR1CNR2BUB1CCR4JAK2 | |
| SCHEMBL15267006 | 0.87 | CNR1 (0.41) | CNR1CNR2BUB1CCR4JAK2 | |
| SCHEMBL25380826 | 0.85 | JAK2 (0.50) | CNR1CNR2BUB1CCR4JAK2 | |
| SCHEMBL31272741 | 0.85 | JAK2 (0.50) | CNR1CNR2BUB1CCR4JAK2 | |
| SCHEMBL31307184 | 0.85 | BUB1 (0.39) | CNR1CNR2BUB1CCR4JAK2 | |
| SCHEMBL15266759 | 0.85 | BUB1 (0.39) | CNR1CNR2BUB1CCR4JAK2 | |
| SCHEMBL31272944 | 0.84 | CNR1 (0.45) | CNR1CNR2BUB1CCR4LMNA | |
| SCHEMBL883677 | 0.84 | CNR1 (0.45) | CNR1CNR2BUB1CCR4LMNA | |
| SCHEMBL883535 | 0.83 | JAK2 (0.48) | CNR1CNR2JAK2LMNATP53 | |
| SCHEMBL10224630 | 0.81 | JAK2 (0.47) | CNR1CNR2JAK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472171-B1 | SUBSTITUTED TRICYCLIC HERTEOCYCLIC COMPOUNDS AND USE THEREOF | SUZHOU YABAO PHARMACEUTICAL R&D CO LTD (CN) | 2025-04-23 | — | — | EP | disclosed |
| CN-109071558-B | Substituted tricyclic heterocyclic compounds and uses thereof | 苏州亚宝药物研发有限公司 | 2021-10-29 | — | — | CN | disclosed |
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | LIFEARC (GB) | 2021-02-16 | — | — | US | disclosed |
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | LIFEARC (GB) | 2021-02-16 | — | — | US | disclosed |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | LIFEARC (GB) | 2019-10-10 | — | — | US | disclosed |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | LIFEARC (GB) | 2019-10-10 | — | — | US | disclosed |
| WO-2017215600-A1 | SUBSTITUTED TRICYCLIC HERTEOCYCLIC COMPOUNDS AND USE THEREOF | SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD. (CN) | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | MAPT, TTBK1, TNK2 | CNR1 1444/4885CNR2 1390/4885BUB1 343/4885 |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | MAPT, NNMT, TKFC | CNR1 953/4885CNR2 757/4885BUB1 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.