Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15998476 | 0.83 | ALDH1A1 (0.46) | KDM4EALDH1A1KAT2BBRD9TDP1 | |
| SCHEMBL28396213 | 0.80 | NR4A3 (0.43) | KDM4CKDM5AKDM5BNR4A3KDM4E | |
| SCHEMBL27919011 | 0.79 | NR4A3 (0.36) | KDM4CKDM5AKDM5BNR4A3KDM4E | |
| SCHEMBL31352094 | 0.77 | KDM4C (0.38) | KDM4CNR4A3KDM4EALDH1A1TDP1 | |
| SCHEMBL4718250 | 0.75 | KDM4C (0.38) | KDM4CKDM5AKDM5BNR4A3KDM4E | |
| SCHEMBL19730080 | 0.75 | GABRA1 (0.33) | KAT2BBRD9NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17853170 | 0.74 | KDM4C (0.42) | KDM4CKDM5AKDM5BNR4A3KDM4E | |
| SCHEMBL4594824 | 0.74 | LPAR1 (0.39) | BRD9NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3519865 | 0.74 | NR4A3 (0.59) | NR4A3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7722135 | 0.74 | KDM4E (0.41) | KDM4CNR4A3KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035774-B2 | Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds | MERCK SHARP & DOHME CORP. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | UROD, PEPD, CMPK1 | KDM4C 2280/4885KDM5A 1623/4885KDM5B 1937/4885 |
| US-10035774-B2 | Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds | UROD, PEPD, CMPK1 | KDM4C 2280/4885KDM5A 1623/4885KDM5B 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.