Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500887 | 1.00 | JAK2 (0.39) | JAK2CCR4PTGER4CNR1CNR2 | |
| SCHEMBL21434366 | 0.92 | JAK2 (0.39) | JAK2CCR4PTGER4CNR1CNR2 | |
| SCHEMBL3775379 | 0.88 | CCR4 (0.39) | JAK2CCR4PTGER4CNR1CNR2 | |
| SCHEMBL3775383 | 0.88 | CCR4 (0.39) | JAK2CCR4PTGER4CNR1CNR2 | |
| SCHEMBL416412 | 0.86 | JAK2 (0.48) | JAK2L3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL416411 | 0.86 | JAK2 (0.48) | JAK2L3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL10225762 | 0.84 | JAK2 (0.47) | JAK2CCR4L3MBTL1ALDH1A1POLB | |
| SCHEMBL3771429 | 0.79 | CNR1 (0.41) | PTGER4CNR1CNR2BUB1L3MBTL1 | |
| SCHEMBL3772381 | 0.79 | CNR1 (0.41) | PTGER4CNR1CNR2BUB1L3MBTL1 | |
| SCHEMBL19730053 | 0.78 | CNR1 (0.43) | JAK2CCR4PTGER4CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017215600-A1 | SUBSTITUTED TRICYCLIC HERTEOCYCLIC COMPOUNDS AND USE THEREOF | SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD. (CN) | 2017-12-21 | — | — | WO | disclosed |