Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500887 | 0.92 | JAK2 (0.39) | JAK2PTGER4ALDH1A1CNR1CNR2 | |
| SCHEMBL19730136 | 0.92 | JAK2 (0.39) | JAK2PTGER4ALDH1A1CNR1CNR2 | |
| SCHEMBL3772381 | 0.87 | CNR1 (0.41) | PTGER4THRBATMLTB4RALDH1A1 | |
| SCHEMBL3771429 | 0.87 | CNR1 (0.41) | PTGER4THRBATMLTB4RALDH1A1 | |
| SCHEMBL13834301 | 0.84 | JAK2 (0.47) | JAK2LTB4RALDH1A1L3MBTL1 | |
| SCHEMBL13834302 | 0.84 | JAK2 (0.47) | JAK2LTB4RALDH1A1L3MBTL1 | |
| SCHEMBL3775383 | 0.80 | CCR4 (0.39) | JAK2PTGER4ALDH1A1CNR1CNR2 | |
| SCHEMBL3775379 | 0.80 | CCR4 (0.39) | JAK2PTGER4ALDH1A1CNR1CNR2 | |
| SCHEMBL19730012 | 0.79 | LMNA (0.43) | JAK2PTGER4ALDH1A1CNR1CNR2 | |
| SCHEMBL416412 | 0.78 | JAK2 (0.48) | JAK2ALDH1A1LMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071558-B | Substituted tricyclic heterocyclic compounds and uses thereof | 苏州亚宝药物研发有限公司 | 2021-10-29 | — | — | CN | disclosed |
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | LIFEARC (GB) | 2021-02-16 | — | — | US | disclosed |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | LIFEARC (GB) | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | MAPT, TTBK1, TNK2 | JAK2 1723/4885PTGER4 2738/4885THRB 951/4885 |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | MAPT, NNMT, TKFC | JAK2 1422/4885PTGER4 2403/4885THRB 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.