Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 3/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | PDE8B | O95263 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 8/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13857900 | 0.90 | IL1B (0.43) | IL1BP2RX7PDE8BBTKFGFR1 | |
| SCHEMBL29588723 | 0.90 | IL1B (0.43) | IL1BP2RX7PDE8BBTKFGFR1 | |
| SCHEMBL13857901 | 0.90 | IL1B (0.43) | IL1BP2RX7PDE8BBTKFGFR1 | |
| SCHEMBL18925739 | 0.90 | IL1B (0.43) | IL1BP2RX7PDE8BBTKFGFR1 | |
| SCHEMBL19731424 | 0.89 | BTK (0.48) | PDE8BBTKFGFR1FGFR4 | |
| SCHEMBL17394767 | 0.82 | TGFBR1 (0.43) | — | |
| SCHEMBL15516736 | 0.82 | PDE8B (0.40) | IL1BP2RX7PDE8BBTKLMNA | |
| SCHEMBL15516738 | 0.82 | PDE8B (0.40) | IL1BP2RX7PDE8BBTKLMNA | |
| SCHEMBL19731380 | 0.81 | TGFBR1 (0.45) | — | |
| SCHEMBL13858254 | 0.80 | BTK (0.47) | PDE8BBTKFGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| WO-2017215485-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-12-21 | — | — | WO | disclosed |