Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 7/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | KDM5C | P41229 | 4/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18378768 | 1.00 | KDM5A (0.43) | KDM5ADRD4DRD2SIGMAR1DRD3 | |
| SCHEMBL18378708 | 1.00 | KDM5A (0.43) | KDM5ADRD4DRD2SIGMAR1DRD3 | |
| SCHEMBL18377696 | 0.90 | DRD4 (0.43) | KDM5ADRD4DRD2SIGMAR1DRD3 | |
| SCHEMBL18378723 | 0.87 | KDM5A (0.36) | KDM5ADRD4DRD2SIGMAR1DRD3 | |
| SCHEMBL18367646 | 0.81 | HTR6 (0.38) | DRD4DRD2SIGMAR1DRD3KCNH2 | |
| SCHEMBL18367651 | 0.81 | HTR6 (0.38) | DRD4DRD2SIGMAR1DRD3KCNH2 | |
| SCHEMBL19726576 | 0.81 | HTR6 (0.38) | DRD4DRD2SIGMAR1DRD3KCNH2 | |
| SCHEMBL8130788 | 0.80 | DRD4 (0.60) | DRD4DRD2SIGMAR1DRD3KCNH2 | |
| SCHEMBL18377687 | 0.80 | KDM5A (0.33) | KDM5A | |
| SCHEMBL18377691 | 0.80 | KDM5A (0.33) | KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | KDM5A 1081/4885DRD4 4722/4885DRD2 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.