Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 17/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | APEX1 | P27695 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19732954 | 1.00 | ADORA2B (0.78) | ADORA2BPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL19752683 | 0.83 | ADORA2B (1.00) | ADORA2BPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL5347733 | 0.83 | ADORA2B (1.00) | ADORA2BPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL27372710 | 0.77 | KDM4E (0.77) | ADORA2BPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL19732955 | 0.77 | USP2 (0.79) | POLBTDP1KDM4EMEN1KMT2A | |
| SCHEMBL13789190 | 0.77 | USP2 (0.79) | POLBTDP1KDM4EMEN1KMT2A | |
| SCHEMBL19732923 | 0.77 | USP2 (0.79) | POLBTDP1KDM4EMEN1KMT2A | |
| SCHEMBL28070114 | 0.77 | ADORA2B (0.60) | ADORA2BPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL16323418 | 0.75 | ADORA2B (0.81) | ADORA2BPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL10794871 | 0.75 | ADORA2B (0.55) | ADORA2BPOLBL3MBTL1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3260446-A1 | ENANTIOSELECTIVE SYNTHESIS OF DIHYDROPYRIMIDINONES AND HEXAHYDROPYRIMIDINONES | Universitat de les Illes Balears (ES) | 2017-12-27 | — | — | EP | disclosed |