Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618139 | 0.80 | APLNR (0.46) | PDE10A | |
| SCHEMBL10328707 | 0.80 | APLNR (0.46) | PDE10A | |
| SCHEMBL16011597 | 0.78 | S1PR3 (0.37) | — | |
| SCHEMBL2693524 | 0.78 | ALDH1A1 (0.37) | PDE10A | |
| SCHEMBL29739695 | 0.78 | PTGS1 (0.36) | PDE10A | |
| SCHEMBL25160107 | 0.78 | PDE10A (0.46) | PDE10A | |
| SCHEMBL2147552 | 0.78 | ALDH1A1 (0.37) | PDE10A | |
| SCHEMBL25700628 | 0.78 | ABL1 (0.33) | PDE10A | |
| SCHEMBL2897054 | 0.76 | ESR1 (0.50) | ESR1ESR2GRIN2BGRIN1 | |
| SCHEMBL20644491 | 0.76 | OGA (0.37) | ESR1ESR2DEGS1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9329185-B2 | Sulfonate compounds | UNIVERSITY OF MASSACHUSETTS (US) | 2016-05-03 | — | — | US | disclosed |
| US-9329185-B2 | Sulfonate compounds | UNIVERSITY OF MASSACHUSETTS (US) | 2016-05-03 | — | — | US | disclosed |
| US-9329185-B2 | Sulfonate compounds | UNIVERSITY OF MASSACHUSETTS (US) | 2016-05-03 | — | — | US | disclosed |
| US-20140275526-A1 | SULFONATE COMPOUNDS | UNIVERSITY OF MASSACHUSETTS (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275526-A1 | SULFONATE COMPOUNDS | UNIVERSITY OF MASSACHUSETTS (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275526-A1 | SULFONATE COMPOUNDS | UNIVERSITY OF MASSACHUSETTS (US) | 2014-09-18 | — | — | US | disclosed |
| US-8609699-B2 | Oxotetrahydrofuran-2-yl-benzimidazole derivative | MSD K.K. (JP) | 2013-12-17 | — | — | US | disclosed |
| EP-2328892-B1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-20110144162-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| EP-2328892-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | MSD K.K. (JP) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010024110-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144162-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | GCK, GCKR, KHK | ESR1 4222/4885ESR2 3764/4885DEGS1 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.