Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | UPP1 | Q16831 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238065 | 0.90 | ALDH1A1 (0.36) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL28686642 | 0.84 | HTT (0.46) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL30692217 | 0.84 | HTT (0.46) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL21686185 | 0.81 | ALDH1A1 (0.38) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL10728519 | 0.80 | KDM4E (0.44) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL4673214 | 0.78 | HTT (0.58) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL11100290 | 0.78 | KMT2A (0.44) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL8650240 | 0.78 | ATM (0.39) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL11826533 | 0.77 | ALDH1A1 (0.37) | ALDH1A1GAAHPGDKDM4EADORA2A | |
| SCHEMBL19716478 | 0.77 | MAPT (0.40) | ALDH1A1GAAHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216727-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |
| WO-2017216726-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |