Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | UPP1 | Q16831 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19734735 | 0.90 | ALDH1A1 (0.43) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL30692217 | 0.80 | HTT (0.46) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL28686642 | 0.80 | HTT (0.46) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL21686185 | 0.77 | ALDH1A1 (0.38) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL19716478 | 0.77 | MAPT (0.40) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL29658702 | 0.77 | MAPT (0.40) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL27528601 | 0.76 | KDM4E (0.33) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL10728519 | 0.76 | KDM4E (0.44) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL4673214 | 0.74 | HTT (0.58) | ALDH1A1GAAHPGDMEN1KMT2A | |
| SCHEMBL11100290 | 0.74 | KMT2A (0.44) | ALDH1A1GAAHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082821-A1 | PROCESS FOR PRODUCING 2,6-DIHYDROXY-3,4-DIALKYLPYRIDINES | ISP INVESTMENTS INC. (US) | 2003-10-09 | — | — | WO | claimed |
| US-6624307-B1 | Reacting 2-cyanoacetamide with sodium methoxide; condensation with ethyl 2-methylacetoacetate in methanol; salt formation to 2,6-dihdroxy-4,5-dimethyl-3-pyridinecabonitrile; hydrolysis, decarboxylation | ISP INVESTMENTS INC. | 2003-09-23 | — | — | US | claimed |
| EP-3634408-B1 | AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME LLC (US) | 2022-12-28 | — | — | EP | disclosed |
| US-10945771-B2 | Azabicyclo[4.1.0]heptane allosteric modulators of the M4 muscarinic acetylcholine receptor | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| EP-3634408-A1 | AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | Merck Sharp & Dohme Corp. (US) | 2020-04-15 | — | — | EP | disclosed |
| US-20200095262-A1 | AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2020-03-26 | — | — | US | disclosed |
| EP-3394061-B1 | 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME (US) | 2020-03-11 | — | — | EP | disclosed |
| US-10351564-B2 | 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor | Merck Sharop & Dohme, Corp. (US) | 2019-07-16 | — | — | US | disclosed |
| US-10329289-B2 | 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor | MERCK SHARP & DOHME CORP. (US) | 2019-06-25 | — | — | US | disclosed |
| WO-2018226545-A1 | AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2018-12-13 | — | — | WO | disclosed |
| EP-3394061-A1 | 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | Merck Sharp & Dohme Corp. (US) | 2018-10-31 | — | — | EP | disclosed |
| WO-2015126751-A1 | IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-08-27 | — | — | WO | disclosed |
| WO-2015126751-A1 | IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-08-27 | — | — | WO | disclosed |
| US-20150232480-A1 | Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-08-20 | — | — | US | disclosed |
| US-20150232480-A1 | Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-08-20 | — | — | US | disclosed |
| US-20150232480-A1 | Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-08-20 | — | — | US | disclosed |
| WO-2003082821-A1 | PROCESS FOR PRODUCING 2,6-DIHYDROXY-3,4-DIALKYLPYRIDINES | ISP INVESTMENTS INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| WO-2003082821-A1 | PROCESS FOR PRODUCING 2,6-DIHYDROXY-3,4-DIALKYLPYRIDINES | ISP INVESTMENTS INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| US-6624307-B1 | Reacting 2-cyanoacetamide with sodium methoxide; condensation with ethyl 2-methylacetoacetate in methanol; salt formation to 2,6-dihdroxy-4,5-dimethyl-3-pyridinecabonitrile; hydrolysis, decarboxylation | ISP INVESTMENTS INC. | 2003-09-23 | — | — | US | disclosed |
| US-6624307-B1 | Reacting 2-cyanoacetamide with sodium methoxide; condensation with ethyl 2-methylacetoacetate in methanol; salt formation to 2,6-dihdroxy-4,5-dimethyl-3-pyridinecabonitrile; hydrolysis, decarboxylation | ISP INVESTMENTS INC. | 2003-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10945771-B2 | Azabicyclo[4.1.0]heptane allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM4, CHRM1, CHRM5 | ALDH1A1 1887/4885GAA 3469/4885HPGD 2073/4885 |
| US-10329289-B2 | 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM5, CHRM4, CHRM1 | ALDH1A1 2056/4885GAA 2969/4885HPGD 1284/4885 |
| US-20150232480-A1 | Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication | EIF2AK2, MAVS, TYMP | ALDH1A1 3105/4885GAA 966/4885HPGD 1529/4885 |
| US-20200095262-A1 | AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | CHRM4, CHRM1, CHRM5 | ALDH1A1 1887/4885GAA 3469/4885HPGD 2073/4885 |
| US-10351564-B2 | 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM5, CHRM4, CHRM1 | ALDH1A1 2056/4885GAA 2969/4885HPGD 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.