Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181463 | 0.84 | KDM4E (0.58) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL951851 | 0.82 | KDM4E (0.59) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31261054 | 0.82 | KDM4E (0.59) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12431662 | 0.82 | KDM4E (0.59) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL951852 | 0.82 | KDM4E (0.59) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13621098 | 0.80 | KDM4E (0.58) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL662972 | 0.79 | KDM4E (0.61) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15007 | 0.79 | KDM4E (0.61) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9000467 | 0.78 | KDM4E (0.56) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL934192 | 0.78 | KDM4E (0.59) | KDM4EL3MBTL1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | KDM4E 1490/4885L3MBTL1 1355/4885SMN1; SMN2 4070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.